清末民初,佛山武学宗师黄飞鸿因噩梦预感女记(jì )者(zhě )莫(mò )十(shí )三(sān )遇(yù )险(xiǎn ),携(xié )弟(dì )子(zǐ )前(qián )往(wǎng )古云村寻人。村中蜈蚣教借蛊术胁迫村民献祭孩童,莫十三探查真相时被擒,身中噬魂蛊。黄飞鸿闯祭坛救人,因不忍伤及被蛊惑的村民反中蛊毒,幸(xìng )得(dé )卧(wò )底(dǐ )蜈(wú )蚣(gōng )教(jiāo )的鬼脚七暗中相助。众人合力破除水源蛊毒,救治村民,鬼脚七伤愈拜师。巫师自焚后,线索指向广州东瀛会馆。黄飞(fēi )鸿(hóng )潜(qián )入(rù )会(huì )馆(guǎn )救(jiù )出(chū )被(bèi )掳(lǔ )孩(hái )童(tóng ),对决主事服部一郎,得知幕后黑手为西洋吸血鬼麦克罗。麦克罗散播疫毒祸乱羊城,以莫十三性命相要挟。黄飞鸿于绝境中融合腿法,悟出佛山无影(yǐng )脚(jiǎo ),击(jī )杀(shā )麦(mài )克(kè )罗。蛊毒尽解,百姓恢复神智,广州重归太平,宝芝林重回烟火日常。